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Musical Genes? They May Even Tell Us Something About Dyslexia

As a four year old, Wolfgang Amadeus Mozart was reported to "play faultlessly and with the greatest delicacy" Behavior like that makes musical talent intriguing and mysterious.

Given that certain families produce abundant numbers of musicians, sci­en­tists have long sus­pected that talent in this realm mu­sic might have ge­net­ic roots. Now research indicates that they may be right. Sci­en­tists in Finland say they’ve found ap­prox­i­mate loca­t­ions in our ge­nome where genes af­fect­ing mu­si­cal tal­ent may lie. The find­ings suggest not only that mu­si­cal abil­ity is partly ge­net­ic but it may share ev­o­lu­tion­ary roots with lan­guage.


The study of 234 Finns from 15 fam­i­lies—all with at least some mu­sicians—was pub­lished in the April 18 ad­vance on­line is­sue of the Jour­nal of Med­i­cal Ge­net­ics.

As part of the re­search, each par­ti­ci­pant al­so took three tests of mu­si­cal ap­ti­tude. The re­search­ers re­ported find­ing “sig­nif­i­cant ev­i­dence” for an as­socia­t­ion be­tween that abil­ity and a small re­gion of Chro­mo­some 4. The patch of DNA in ques­tion en­com­passed about 50 genes. Of par­tic­u­lar in­ter­est was one gene that in­ter­acts with mo­le­cules that gov­ern the de­vel­op­ment of brain cells and their intercon­nec­tions. Mu­ta­tions in the gene are al­so in­di­rectly linked to de­fects in time and pitch pro­cess­ing. There’s al­so ev­i­dence such mutations may be con­nect­ed to the dys­lex­ia.

Interestingly, a second sep­a­rate group re­ported in the April 16 ad­vance on­line is­sue of the Jour­nal of Cog­ni­tive Neu­ro­sci­ence that chil­dren with lan­guage syn­tax deficits al­so have mu­si­cal dif­fi­cul­ties .

These stu­dies, while too small to be de­fin­i­tive, are good start­ing points for fur­ther map­ping, isola­t­ion, and description of genes that may help us account for the Mozarts of the world--and at the same time, the children who struggle with the printed page.


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